TRANSFAL

THE TRANSFAL PROJECT IS A SUB-STUDY WITHIN THE PARSIFAL CLINICAL TRIAL. THE INITIAL GOAL WILL BE TO ANALYZE THE MOLECULAR TUMOR PROFILE AT THE TIME OF PROGRESSION IN PATIENTS WITH MODERATE SENSITIVITY TO PALBOCICLIB IN COMBINATION WITH FIRST-LINE ENDOCRINE THERAPY. FOR THIS PURPOSE, DIFFERENT MOLECULAR APPROACHES, SUCH AS DIFFERENTIAL PROTEOMICS, IN VIVO PDX MODELS, FISH, DNA SEQUENCING, WILL BE RUN ON AN INITIAL SUBSET OF THE PARSIFAL POPULATION.