PHERGAIN-2

TRASTUZUMAB, PERTUZUMAB AND TDM1 FOR HER2+ EARLY BREAST CANCER

CLINICAL TRIAL DETAILS

THIS CLINICAL TRIAL EVALUATES THE EFFICACY OF A CHEMOTHERAPY-FREE PATHOLOGICAL COMPLETE RESPONSE (PCR)-GUIDED STRATEGY WITH TRASTUZUMAB AND PERTUZUMAB (GIVEN AS A SUBCUTANEOUS FIXED-DOSE COMBINATION) AND T-DM1, FOR PATIENTS WITH PREVIOUSLY UNTREATED HER2-POSITIVE EARLY BREAST CANCER, BY ASSESSING THE 3-YEAR RECURRENCE FREE INTERVAL (3Y-RFI). IN ADDITION, THE TRIAL WILL ASSESS THE GLOBAL HEALTH STATUS DECLINE RATE AT 1 YEAR FROM START OF NEOADJUVANT TREATMENT IN THIS TARGET POPULATION.

PHERGAIN-2

COUNTRY

STATUS

TUMOR TYPE

PHASE

SITES

HER2+ EBC

393

Spain, Italy, Germany, Hungary, Bulgaria, Poland

Analysis

TRIAL OVERVIEW

PRESS RELEASE

2021 Press Release

SCIENTIFIC IMPACT

SABCS 2021 poster

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TRIAL SITES

Hospital General Universitario de Valencia (Spain) Hospital Universitari Dexeus (Spain) Hospital Arnau de Vilanova de Valencia (Spain) Hospital Universitario Virgen del Rocío (Spain) Hospital Universitari Sant Joan de Reus (Spain) Hospital Universitario Ramón y Cajal (Spain) Hospital Universitario de Basurto (Spain) Hospital General Universitario de Alicante (Spain) Hospital Provincial de Castellón (Spain) Instituto Valenciano de Oncología (Spain) Complejo Hospitalario de Jaén (Spain) Complejo Hospitalario Universitario A Coruña (CHUAC) (Spain) Hospital Universitario Reina Sofía (Spain) Hospital Clínico Universitario de Valencia (Spain) Institut Català d'Oncologia L'Hospitalet (ICO) (Spain) Hospital Clínico San Carlos (Spain) Hospital Universitario de León (Spain) Hospital Universitari Vall D'Hebrón (Spain) Hospital Quiron San Camilo-Ruber Juan Bravo (Spain) Hospital Universitario Clínico San Cecilio de Granada (Spain) Institut Català d'Oncologia Badalona (ICO) (Spain) Centro Oncológico de Galicia (Spain) Hospital Universitario de Torrejón (Spain) Hospital Arnau de Vilanova de Lleida (Spain)

Dr. Cortes and Dr. Llombart PHERain interview

Beyond Chemotherapy

Dr. Vanes Quiroga

Dr. Sofia Braga

Dr. Silvi Antolín

Dr. Escrivá de Romaní

Dr. Philipp Aftimos

Dr. Manuel Ruiz

Prof. Daniele Generali PHEGain interview

Dr. Jacques Medioni

Dr. Dunca Wheatley