TUXEDO-3

MULTICENTER, SINGLE-ARM, 3 COHORT, PHASE II TRIAL OF HER3-DXd IN PATIENTS WITH ACTIVE BRAIN METASTASES FROM METASTATIC BREAST CANCER AND NON-SMALL CELL LUNG CANCER, AND IN PATIENTS WITH LEPTOMENINGEAL DISEASE FROM ADVANCED SOLID TUMORS

https://clinicaltrials.gov/study/NCT05865990

Breast cancer and NSCLC with brain metastases; Leptomeningeal disease

Spain, Austria

Follow up

CLINICAL TRIAL DETAILS

TO ANALYZE THE EFFICACY OF PATRITUMAB DERUXTECAN (HER3-DXd) AS DETERMINED BY INTRACRANIAL OBJECTIVE RESPONSE RATE (ORR-IC) PER LOCAL INVESTIGATOR AS JUDGED BY BEST CNS RESPONSE ACCORDING TO RANO-BM CRITERIA IN PATIENTS WITH ACTIVE BRAIN METASTASES FROM METASTATIC BREAST CANCER (COHORT 1) AND ADVANCED NSCLC (COHORT 2), AND TO ASSESS OVERALL SURVIVAL AT 3 MONTHS IN PATIENTS WITH LEPTOMENINGEAL DISEASE FROM ADVANCED SOLID TUMORS (COHORT 3).

TUMOR TYPE

PHASE

SITES

COUNTRY

STATUS

PRESS RELEASE

SCIENTIFIC IMPACT

ASCO 2024 poster: https://www.medsir.org/_files/ugd/39f166_9261f09436c34ee8848fd5ca5936bde4.pdf | ASCO 2024 lay language summary: https://www.medsir.org/_files/ugd/39f166_8df4fbcf60e447d49e93b4dc8461402a.pdf | ASCO 2025 presentation: https://www.medsir.org/_files/ugd/39f166_0968706d48d045ee979bc274fc8c6bee.pdf | ASCO 2025 lay language summary: https://www.medsir.org/_files/ugd/39f166_e97e1660ef6e483881d404337aa6387f.pdf | Nature Medicine 2025 publication (select results) | Neuro-Oncology 2025 publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448835/

BLOG ARTICLES RELATED

PHERGAIN SITES

Hospital Arnau de Vilanova de Valencia (Spain) | Hospital Universitari Dexeus (Spain) | Hospital Quirónsalud Sagrado Corazón (Spain) | Hospital Ruber Internacional (Spain) | Hospital Universitari Vall D’Hebron (Spain) | Hospital Universitario Virgen del Rocío (Spain) | Medical University of Vienna (Austria) | Medizinische Universität Innsbruck (Austria) | Salzburg Cancer Research Institute (Austria)

Dr. Cortes and Dr. Llombart PHERain interview

Beyond Chemotherapy

Dr. Vanes Quiroga

Dr. Sofia Braga

Dr. Silvi Antolín

Dr. Escrivá de Romaní

Dr. Philipp Aftimos

Dr. Manuel Ruiz

Prof. Daniele Generali PHEGain interview

Dr. Jacques Medioni

Dr. Dunca Wheatley