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TRANSFAL

SUB-STUDY OF PREDICTIVE BIOMARKERS FOR PALBOCICLIB AND ENDOCRINE THERAPY IN ER+/HER2- ADVANCED BREAST CANCER

https://clinicaltrials.gov/ct2/show/NCT02491983

BREAST

52

280

Sub-study

Spain, France, Italy, UK, Germany, Czech Republic, Russia

Closing

CLINICAL TRIAL DETAILS

THE TRANSFAL PROJECT IS A SUB-STUDY WITHIN THE PARSIFAL CLINICAL TRIAL. THE INITIAL GOAL WILL BE TO ANALYZE THE MOLECULAR TUMOR PROFILE AT THE TIME OF PROGRESSION IN PATIENTS WITH MODERATE SENSITIVITY TO PALBOCICLIB IN COMBINATION WITH FIRST-LINE ENDOCRINE THERAPY. FOR THIS PURPOSE, DIFFERENT MOLECULAR APPROACHES, SUCH AS DIFFERENTIAL PROTEOMICS, IN VIVO PDX MODELS, FISH, DNA SEQUENCING, WILL BE RUN ON AN INITIAL SUBSET OF THE PARSIFAL POPULATION.

TUMOR TYPE

PHASE

N

SITES

COUNTRY

STATUS

PRESS RELEASE

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SCIENTIFIC IMPACT

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AACR 2024 - PARSIFAL-LONG substudy (transFAL) lay language summary: https://www.medsir.org/_files/ugd/39f166_d48da3cca8194199bcc85264b222e648.pdf | AACR - PARSIFAL-LONG substudy (transFAL) poster: https://static.wixstatic.com/media/39f166_4b3c83a81ffa46d5875ca0818f0052ec~mv2.jpg | ESMO 2020 presentation: https://39f1664e-7766-40bf-9b5a-e3575d54bba6.usrfiles.com/ugd/39f166_692b7adb9de44503892ed00c635b5d69.pdf | SABCS 2019 poster: https://39f1664e-7766-40bf-9b5a-e3575d54bba6.usrfiles.com/ugd/39f166_bcec3ba15b26418f890fbd57fbcb727d.pdf

BLOG ARTICLES RELATED

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Dr. Marta Palafox presents results from the TRANSFAL sub-study at ESMO 2020: https://www.medsir.org/post/dr-marta-palafox-presents-results-from-the-transfal-sub-study-at-esmo-2020 | MEDSIR to present results of two of our research projects this year at ESMO 2020!: https://www.medsir.org/post/medsir-to-present-results-of-two-of-our-research-projects-this-year-at-esmo-2020 | First results of the transFAL study in SABCS 2019: https://www.medsir.org/post/first-results-of-the-transfal-study-in-sabcs19

PHERGAIN SITES

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Dr. Cortes and Dr. Llombart PHERain interview
Beyond Chemotherapy
Dr. Vanes Quiroga
Dr. Sofia Braga
Dr. Silvi Antolín
Dr. Escrivá de Romaní
Dr. Philipp Aftimos
Dr. Manuel Ruiz
Prof. Daniele Generali PHEGain interview
Dr. Jacques Medioni
Dr. Dunca Wheatley
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