PHENOMENAL

MULTICENTER OPEN-LABEL, PHASE II TRIAL, TO EVALUATE THE EFFICACY AND SAFETY OF NAL-IRI FOR PROGRESSING BRAIN METASTASES IN PATIENTS WITH HER2-NEGATIVE BREAST CANCER (THE PHENOMENAL STUDY).

https://clinicaltrials.gov/study/NCT03328884

HER2-NEGATIVE MBC

Spain

Closing

CLINICAL TRIAL DETAILS

MULTICENTER OPEN-LABEL, PHASE II TRIAL, TO EVALUATE THE EFFICACY AND SAFETY OF NAL-IRI IN PATIENTS WITH HER2-NEGATIVE BREAST CANCER, WHO HAVE DOCUMENTED CENTRAL NERVOUS SYSTEM (CNS) PROGRESSION FOLLOWING WHOLE BRAIN RADIO THERAPY (WBRT), STEREOTACTIC RADIOSURGERY (SRS) AND/OR SURGERY, AS DETERMINED BY THE RESPONSE ASSESSMENT IN NEURO-ONCOLOGY BRAIN METASTASES (RANO-BM) CRITERIA.

TUMOR TYPE

PHASE

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PRESS RELEASE

2021 Press Release: https://www.medsir.org/post/phenomenal-study-breast

SCIENTIFIC IMPACT

SABCS 2024 poster: https://www.medsir.org/_files/ugd/39f166_c925473a09004ea5ad3207cf3484b6a9.pdf | SABCS 2024 lay language summary: https://www.medsir.org/_files/ugd/39f166_876cbe4b70784c299f9b1e2c09a8b68d.pdf | AACR 2018 poster: https://39f1664e-7766-40bf-9b5a-e3575d54bba6.usrfiles.com/ugd/39f166_38b5d848657a4d79b69678890c96d432.pdf

BLOG ARTICLES RELATED

Up to 30% of patients with metastatic breast cancer develop brain disease: https://www.medsir.org/post/up-to-30-of-patients-with-metastatic-breast-cancer-develop-brain-disease | We explore new ways to treat breast cancer with brain metastases: https://www.medsir.org/post/we-explore-new-ways-to-treat-breast-cancer-with-brain-metastases | PHENOMENAL Study reach a New Milestone!: https://www.medsir.org/post/phenomenal-study-reach-a-new-milestone

PHERGAIN SITES

Instituto Oncológico Baselga - Hospital Quiron Salud Barcelona (Spain) | Hospital Universitari Sant Joan de Reus (Spain) | MD Anderson Cancer Center Madrid (Spain) | Hospital Clínico San Carlos (Spain) | Hospital Universitario Doce de Octubre (Spain) | Hospital Universitario Miguel Servet (Spain) | Institut Català d'Oncologia Badalona (ICO) (Spain) | Hospital Universitario Clínico San Cecilio de Granada (Spain) | Hospital Universitario Virgen de la Victoria (Spain) | Hospital Universitario Ramón y Cajal (Spain) | Instituto Valenciano de Oncología (IVO) (Spain) | Hospital Universitario Virgen del Rocío (Spain) | Hospital Universitari Son Espases (Spain) | Hospital Son Llatzer (Spain) | Ruber Juan Bravo – Hospital Quirón (Spain) | Hospital Universitario Virgen de las Nieves (Spain)

Dr. Cortes and Dr. Llombart PHERain interview

Beyond Chemotherapy

Dr. Vanes Quiroga

Dr. Sofia Braga

Dr. Silvi Antolín

Dr. Escrivá de Romaní

Dr. Philipp Aftimos

Dr. Manuel Ruiz

Prof. Daniele Generali PHEGain interview

Dr. Jacques Medioni

Dr. Dunca Wheatley