PALMIRA

OFFICIAL TITLE: PALBOCICLIB RECHALLENGE IN HORMONE RECEPTOR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER – PALMIRA.

PROJECT DETAILS

INTERNATIONAL, MULTICENTER, RANDOMIZED, OPEN-LABEL, PHASE II CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF CONTINUATION OF PALBOCICLIB IN COMBINATION WITH SECOND-LINE ENDOCRINE THERAPY IN HORMONE RECEPTOR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER PATIENTS WHO HAVE ACHIEVED CLINICAL BENEFIT DURING FIRST-LINE PALBOCICLIB-BASED TREATMENT.

THE PRIMARY GOAL IS TO COMPARE THE EFFICACY, DEFINED AS PROGRESSION-FREE SURVIVAL (PFS), OF CONTINUATION OF PALBOCICLIB TREATMENT COMBINED WITH SECOND-LINE ENDOCRINE THERAPY (FULVESTRANT OR LETROZOLE) VERSUS ENDOCRINE THERAPY ALONE IN PRE- AND POST-MENOPAUSAL WOMEN WITH HR-POSITIVE/HER2-NEGATIVE ADVANCED BREAST CANCER (ABC).

IN ADDITION, TO EXPLORE POTENTIAL MOLECULAR MARKERS OF SENSITIVITY AND/OR RESISTANCE FOR THE COMBINATION AND ENDOCRINE THERAPY ALONE.

 

PALMIRA AT CLINICALTRIALS.GOV

TUMOR TYPE

PHASE

N

SITES

COUNTRY

STATUS

HER2+ EBC

II

198

54

Spain, France, Italy, UK, Germany

Recruiting

ESMO  2019 – DOWNLOAD THE POSTER

ESMO  2019 – DOWNLOAD  LIST OF COI'S

PALMIRA SITES

SPAIN

Hospital Arnau de Vilanova de Valencia

SPAIN

Instituto Valenciano de Oncología (IVO)

SPAIN

Hospital Universitari i Politècnic La Fe

SPAIN

Consorci Hospital General Universitari de València

SPAIN

Hospital Provincial de Castellón

SPAIN

Hospital Universitari Vall D'Hebron

SPAIN

Hospital del Mar

SPAIN

Instituto Oncológico Baselga - Hospital Quiron Salud Barcelona

SPAIN

Institut Català d' Oncologia L'Hospitalet (ICO)

SPAIN

Institut Català d' Oncologia Badalona (ICO)

SPAIN

Institut Català d' Oncologia Girona (ICO)

SPAIN

Consorci Hospitalari de Terrassa

SPAIN

Hospital Universitari Sant Joan de Reus

SPAIN

Hospital Universitario Arnau de Vilanova de Lleida

SPAIN

Hospital Universitari Son Espases

SPAIN

Hospital Clínico Universitario Lozano Blesa

SPAIN

Hospital Universitario Miguel Servet

SPAIN

Hospital Clínico San Carlos

SPAIN

Hospital Universitario La Paz

SPAIN

Hospital Universtitario Sanchinarro

SPAIN

Hospital Universitario de Basurto

SPAIN

Centro Oncológico de Galicia

SPAIN

Hospital Álvaro Cunqueiro

SPAIN

Hospital Universitario Virgen del Rocío

SPAIN

Hospital Universitario Virgen de la Macarena

SPAIN

Hospital Regional Universitario de Málaga (Hospital Carlos Haya)

SPAIN

Hospital San Pedro de Alcántara

SPAIN

Hopital Europeen Georges Pompidou

SPAIN

Hôpital Tenon AP-HP

FRANCE

Centre Paul Strauss

FRANCE

Hôpital Jean Minjoz

FRANCE

Centre Georges François Leclerc

FRANCE

Hospital Center Departmental Vendée

FRANCE

Instituto Europeo di Oncologia

ITALY

Ospedale Civili Brescia

ITALY

Oncologia Medica Ospedale di Prato

ITALY

SSD Oncologia Addarii Zamagni

ITALY

Policlinico Universitario Campus Bio-medico, Roma

UK

Barts Cancer Institute

UK

Beatson West of Scotland Cancer Center, Glasgow

UK

Institute Paoli Calmettes at Marseille

UK

Institut Universitaire du Cancer Toulouse, Toulouse

UK

Ospedale San Raffaello

UK

IRCC Candiolo

UK

The Christie NHS Foundation Trust

UK

Hospital Álvaro Cunqueiro

UK

Kent Oncology Centre, Maidstone