EXCAAPE

OFFICIAL TITLE: A PHASE II CLINICAL TRIAL OF RADIUM-223 ACTIVITY IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) WITH ASYMPTOMATIC PROGRESSION WHILE ON ABIRATERONE ACETATE OR ENZALUTAMIDE BESIDES AR-V7 MUTATIONAL STATUS.

PROJECT DETAILS

RADIUM-223 IS INDICATED FOR THE TREATMENT OF PATIENTS WITH MCRPC WITH SYMPTOMATIC BONE METASTASES AND NO KNOWN VISCERAL METASTATIC DISEASE. HOWEVER, VERY FEW DATA HAVE BEEN REPORTED IN PATIENTS WITH MCRPC WHO ARE ASYMPTOMATIC OR MILDLY SYMPTOMATIC. RECENTLY, RESULTS FROM AN INTERNATIONAL EXPANDED ACCESS PROGRAM HAVE ALSO SUGGESTED A BENEFIT OF RADIUM-223 IN ASYMPTOMATIC PATIENTS WITH MCRPC. IN ADDITION, THE MECHANISM OF ACTION OF RADIUM-223 SHOULD NOT BE CORRELATED WITH THE PRESENCE/ABSENCE OF THE AR-V7 MUTATION, ALTHOUGH THIS ISSUE HAS NOT YET BEEN EVALUATED.

THE AIM OF THIS STUDY IS TO ASSESS THE EFFICACY OF RADIUM-223 IN ASYMPTOMATIC PATIENTS WITH MCRPC, AND TO ESTABLISH THE ASSOCIATION BETWEEN AR-V7 STATUS AND RADIUM-223 ACTIVITY.

 

 

EXCAAPE AT CLINICALTRIALS.GOV

TUMOR TYPE

PHASE

N

SITES

COUNTRY

STATUS

mCRPC

II

52

9

Spain

Recruitment  closed

ESMO 2017 – DOWNLOAD THE POSTER

EXCAAPE SITES

Hospital Universitario Miguel Servet

SPAIN

Complejo Hospitalario de Jaén

SPAIN

Hospital Parc TaulíHospital Universitario Ramón y Cajal

SPAIN

Hospital Universitario La Paz

SPAIN

Hospital Universitario de León

SPAIN

Hospital Son Llatzer

SPAIN

Hospital Universitari Dexeus

SPAIN

Hospital Universitario Dr. Peset

SPAIN

Institut Català d' Oncologia Girona (ICO)

SPAIN